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2 and Table 2)

For example, the compound 13 (racemic) is a very week IRAP inhibitor (Lukaszuk et al., 2011) and compound 14 with a 4-hydroxydiphenylmethane scaffold as a substitute for Tyr 2 is essentially inactive (Figure 4) (Andersson et al., 2008)

Microglial energy metabolism is gaining prominence in neurodegenerative disorders, as numerous brain diseases are associated with changes in brain energy metabolism and constant inflammation